a 33 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T36832	PDE4B-IN-2	A 33	PDE
	PDE4B-IN-2 (A 33) is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects.		PDE
T6433	CAY10505		Apoptosis , PI3K
	CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).		Apoptosis , PI3K
TP1039	Secretin (33-59), rat	Secretin (rat)	Glucagon Receptor
	Secretin (33-59), rat (Secretin (rat)) is a classical hormone in the gastrointestinal system and a neuropeptide.		Glucagon Receptor
T76910	Astegolimab	RG 6149,MSTT 1041A	Interleukin
	Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe ast...		Interleukin
T12216	NF-56-EJ40		GPR
	NF-56-EJ40 is an effective and highly selective antagonist of human SUCNR1 with an IC50 of 25 nM and a Ki of 33 nM.		GPR
T62929	RLX-33		ERK , RXFP receptor
	RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation. RLX-33 can block the increase in food intake ...		ERK , RXFP receptor
T6840	FRAX486		PAK
	FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.		PAK
T6725	VU 0357121		GluR
	VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.		GluR
T19618	(R)-(-)-JQ1 Enantiomer		Epigenetic Reader Domain
	(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)		Epigenetic Reader Domain
T60067	WAY-297174		Casein Kinase
	WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.		Casein Kinase
T12110	MRZ 2-514	8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one	NMDAR
	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.		NMDAR
T6840L	FRAX486 HCL(1232030-35-1 free base)		PAK
	FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.		PAK
T5443	JQ-1 (carboxylic acid)	JQ-1 carboxylic acid	Epigenetic Reader Domain
	JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)		Epigenetic Reader Domain
T13119	Tenalisib	RP6530	PI3K
	Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)		PI3K
TP1973L	OXA (17-33) acetate		OX Receptor
	OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).		OX Receptor
T14364	AZ-Dyrk1B-33	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine	DYRK
	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.		DYRK
T5884	Chelidamic acid		GluR
	Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.		GluR
T2505	S3I-201	S3I 201,S3I201	STAT
	S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.		STAT
T2395L	Vortioxetine hydrobromide	Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,Lu AA21004 hydrobromide	5-HT Receptor , Serotonin Transporter
	Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).		5-HT Receptor , Serotonin Transporter
T6110	YM-201636		Influenza Virus , PI3K , Autophagy
	YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.		Influenza Virus , PI3K , Autophagy